Updated: July 22, 2025

Maintaining the health of feedlot cattle is crucial for ensuring optimal growth, minimizing disease outbreaks, and maximizing profitability. One of the cornerstones of effective herd health management is a well-designed vaccination protocol. Vaccinations help stimulate the immune system to protect cattle from various infectious diseases commonly encountered in feedlot environments. This article explores the essential vaccination protocols for feedlot cattle health, highlighting the importance of timing, vaccine selection, administration techniques, and integration with overall herd health management.

Understanding the Importance of Vaccination in Feedlots

Feedlots are environments where cattle are confined at high densities, typically fed a high-energy diet to promote rapid weight gain before slaughter. The close proximity of animals increases the risk of disease transmission, particularly respiratory infections, which are among the leading causes of morbidity and mortality in feedlot cattle. Vaccination serves as a preventive measure to reduce disease incidence, improve animal welfare, and enhance production efficiency.

Diseases such as Bovine Respiratory Disease Complex (BRDC), clostridial infections, infectious bovine rhinotracheitis (IBR), bovine viral diarrhea (BVD), and leptospirosis can cause significant economic losses if not properly controlled. Effective vaccination programs target these pathogens to help safeguard animal health.

Key Diseases Targeted by Feedlot Vaccination Protocols

Before designing or implementing a vaccination program, it is important to understand the primary diseases that impact feedlot cattle:

1. Bovine Respiratory Disease Complex (BRDC)

Often called “shipping fever,” BRDC is a multifactorial disease caused by viral and bacterial pathogens including infectious bovine rhinotracheitis virus (IBR), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), parainfluenza-3 virus (PI3), Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni. Stressors such as weaning, transportation, commingling, and environmental changes predispose cattle to BRDC.

2. Clostridial Diseases

Clostridial bacteria cause diseases like blackleg, malignant edema, and tetanus. These conditions often cause sudden death and are associated with wounds or contamination in the environment.

3. Leptospirosis

Leptospira bacteria can cause fever, abortion in pregnant cows, kidney damage, and decreased performance.

4. Other Viral Diseases

Aside from IBR and BVDV associated with BRDC, other viruses like parainfluenza-3 (PI3) and BRSV also compromise respiratory health.

Components of an Effective Vaccination Program

Vaccine Selection

Selecting appropriate vaccines depends on the regional prevalence of diseases, farm history, risk factors related to animal sourcing and management practices. Combination vaccines that protect against multiple respiratory viruses are widely used due to their convenience and broad coverage.

Vaccines commonly recommended for feedlot cattle include:

  • Modified live virus (MLV) vaccines for IBR, BVDV types 1 & 2, PI3, BRSV
  • Clostridial bacterins/toxoids to prevent blackleg and other clostridial diseases
  • Leptospira bacterins covering common serovars such as L. pomona, L. hardjo
  • Pasteurella/Mannheimia bacterial vaccines to reduce bacterial pneumonia severity

Timing of Vaccination

Timing is critical to maximize immunity before cattle encounter stressors that increase disease susceptibility:

  • Preconditioning period: Ideal vaccinations occur during preconditioning (usually 45 days before weaning or shipping) when calves are still with their dams. This reduces stress-associated immunosuppression.

  • At arrival: Upon arrival at the feedlot or auction market, boost vaccination with modified live vaccines to rapidly stimulate immune responses.

  • Booster doses: Follow label recommendations for booster vaccinations if required; many MLV vaccines require two doses spaced 2-4 weeks apart for full protection.

Vaccine Administration Practices

Proper administration techniques are essential to ensure vaccine efficacy:

  • Route: Most viral respiratory vaccines are given intramuscularly or subcutaneously according to label instructions.

  • Injection site: Use recommended injection sites such as the neck muscle for easy identification and meat quality concerns.

  • Needle use: Use sterile needles of appropriate gauge and length; change needles frequently to avoid contamination and minimize injection site reactions.

  • Handling: Store vaccines at recommended temperatures (usually refrigerated) and reconstitute MLV vaccines immediately before use.

Record Keeping

Maintaining detailed records of vaccinations—dates administered, vaccine type/batch number, animal identification—is vital for monitoring herd immunity status and managing future vaccination schedules.

Integrating Vaccination into Overall Herd Health Management

While vaccines play a pivotal role in disease prevention, they must be combined with other management practices:

Biosecurity Measures

Minimizing introduction of pathogens through quarantine protocols for incoming animals helps reduce disease pressure.

Nutritional Support

Proper nutrition strengthens immune function; ensuring adequate energy, protein, vitamins (especially A and E), and minerals supports vaccine responsiveness.

Stress Reduction

Handling practices that minimize stress during transport, processing, and feeding improve vaccine efficacy by reducing immunosuppression.

Parasite Control

Effective control of internal and external parasites prevents additional health burdens on animals’ immune systems.

Common Challenges in Feedlot Vaccination Programs

Despite best efforts, several challenges can compromise vaccination success:

  • Maternal antibody interference: In young calves, maternal antibodies acquired through colostrum can neutralize vaccines containing live viruses before effective immunity develops.

  • Improper handling/storage: Exposure of vaccines to heat or freezing can reduce potency.

  • Stress-induced immunosuppression: Transport or environmental stress at arrival may blunt immune responses even post-vaccination.

  • Pathogen variability: Antigenic variation among field strains can occasionally reduce vaccine effectiveness.

Ongoing consultation with veterinarians to tailor protocols to specific operations helps mitigate these issues.

Conclusion

A thorough vaccination protocol is an indispensable component of feedlot cattle health management. By targeting key diseases such as BRDC pathogens, clostridial bacteria, leptospirosis agents, and other respiratory viruses with strategically timed vaccinations using appropriate products administered correctly, producers can significantly reduce disease incidence and improve animal welfare.

Integration with sound biosecurity practices, good nutrition, stress reduction measures, and parasite control further enhances overall herd immunity. Regular evaluation of vaccination outcomes and close collaboration with veterinary professionals ensure that protocols remain aligned with evolving challenges in feedlot production systems.

Investing time and resources into establishing robust vaccination protocols ultimately contributes to healthier cattle populations, improved feed efficiency, reduced treatment costs, and increased profitability within feedlot operations.

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